Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

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Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells

Murine Th1 and Th2 subsets differ not only in the lymphokines they produce, but also functionally. It is not clear what factors influence the preferential activation of one subset versus the other and what regulatory interactions exist between them. The purpose of this study was to examine the effect of lymphokines produced by clones of Th1 cells (IL-2 and IFN-gamma), Th2 cells (IL-4), and APC ...

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In this report we present evidence that Con A-activated T helper 2 cells transcribe the interleukin 2 (IL-2) gene when cycloheximide is added 3 hr after stimulation. This IL-2 mRNA can be translated into functional protein. However, no steady-state mRNA for gamma-interferon can be detected under the same experimental conditions. Furthermore, when cycloheximide is administered at time 0 of activ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1988

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.168.2.543